منابع مشابه
Sodium/calcium exchange: its physiological implications.
The Na+/Ca2+ exchanger, an ion transport protein, is expressed in the plasma membrane (PM) of virtually all animal cells. It extrudes Ca2+ in parallel with the PM ATP-driven Ca2+ pump. As a reversible transporter, it also mediates Ca2+ entry in parallel with various ion channels. The energy for net Ca2+ transport by the Na+/Ca2+ exchanger and its direction depend on the Na+, Ca2+, and K+ gradie...
متن کاملSodium-calcium exchange in the heart.
The sodium calcium exchange (NCX) was first discovered in cardiac muscle1 and squid axon2 and has since been found in most cell types (see reviews3,4). It accounts for the previously observed effects of sodium on cardiac contractility.5 The exchanger transports 3 Na ions per Ca .6–8 This stoichiometry has three important consequences.1 Ca fluxes and hence intracellular Ca concentration ([Ca ]i)...
متن کاملSodium-calcium exchange: the phantom menace.
Researchers have been aware of the existence of a membrane transporter in cardiac myocytes that exchanged calcium for sodium for more than 30 years.1 In that period of time, even as the molecular details of the sodium-calcium exchanger (NaCaX) were being worked out, its physiological role had still not been clearly defined. Early reports focused on the role of the exchanger as an important sour...
متن کاملSodium/calcium exchange in rat cortical astrocytes.
Regulation of the cytosolic free Ca2+ concentration ([Ca2+]cyt) by an Na/Ca exchanger was studied in primary cultured rat cortical astrocytes. [Ca2+]cyt was measured by digital imaging in cells loaded with fura-2. The resting [Ca2+]cyt, approximately 150 nM, was only slightly increased by reducing the extracellular Na+ concentration ([Na+]o) to 6.2 mM, or by treating the cells with ouabain for ...
متن کاملAllosteric Activation of Sodium–Calcium Exchange Activity by Calcium
The activity of the cardiac Na+/Ca2+ exchanger is stimulated allosterically by Ca2+, but estimates of the half-maximal activating concentration have varied over a wide range. In Chinese hamster ovary cells expressing the cardiac Na+/Ca2+ exchanger, the time course of exchange-mediated Ca2+ influx showed a pronounced lag period followed by an acceleration of Ca2+ uptake. Lag periods were absent ...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 1999
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.85.11.982